The use of fibre reinforced polymer (FRP) as a strengthening material for reinforced concrete structures to resist blast loads has attracted great interests in recently years. The structural responses of FRP-strengthened reinforced concrete panels under blast loads are investigated intensively in this paper by employing a finite element model recently developed by the authors. The effects of the thickness of the strengthening FRP sheet, the retrofitted surface, the standoff distance and the mass of the charge on the structural behavior of the reinforced concrete panels under blast loads are studied. The results of the parametric study are analyzed and presented in this paper.