Multi-cell tubes have been drawn increasing attention for their excellent energy-absorbing ability. However, the effect of cell number and oblique loads on crashing behaviors is seldom studied to date. In this paper, a group of multi-cell tubes with different cell numbers are comprehensively investigated under both axial and oblique loads. The finite element models are first established and then validated by experimental tests. The simulation results show that the increase in cell number can be beneficial to the energy absorption (EA) but detrimental due to increase in peak force (F_max) under axial load. When the oblique loads are taken into account, the tubes could undergo global bending, which is an inefficient deformation mode.