Last modified: 2017-05-13
Abstract
Objects: To investigate the association of simultaneously measured limbs blood pressures with Ankle-Brachial Index as the current non-invasive diagnosis method of peripheral artery disease in clinical primary care.
Methods: 228 subjects (61 males, mean age, 63.92±10.72 years; 167 females, mean age, 59.47±7.33 years) were enrolled. Limbs blood pressure measurements were simultaneously performed using a blood pressure and pulse monitor device in the supine position. Data were statistically analyzed with SPSS 15.0.
Results: The mean age of the 229 subjects was 60.66±8.58 years. Variance analysis presented that RABI and LABI have significant differences with inter-arm difference in SBP (≥10 mmHg VS < 10 mmHg,≥10 mmHg VS ≥15 mmHg and≥15 mmHg VS < 10 mmHg). RABI have significant differences with inter-ankle difference in DBP (≥15 mmHg VS < 10 and≥10 mmHg VS ≥15 mmHg). Multinomial logistic regression analysis presented that LABI (<0.9; OR, 10.028; CI, (1.109-90.682); P=0.040) was independently associated with inter-arm SBP difference ≥ 10mmHg; LABI (<0.9; OR, 15.469; CI, (1.776-134.773); P=0.013) and RABI (0.90-1.00; OR, 4.231; CI, (1.205-14.860); P=0.024) were independently associated with inter-arm SBP difference ≥ 15mmHg. RABI (<0.9; OR, 7.189; CI, (1.010-51.179); P=0.049) and RABI (0.90-1.00; OR, 6.273; CI, (1.783-22.077); P=0.004) were independently associated with inter-ankle SBP difference≥ 15mmHg. LABI (0.90-1.00; OR, 4.331; CI, (1.039-14.330); P=0.016) was independently associated with inter-ankle DBP difference of ≥ 10mmHg. After excluding 99 hypertension patients, LABI (<0.9; OR, 246.330; CI, (5.442-11191.384); P=0.005) was still independently associated with inter-arm SBP difference ≥ 15mmHg.
Conclusion: LABI <0.9 was independently associated with inter-arm SBP difference ≥ 15mmHg, while these differences still existed after excluding 99 hypertensive patients. In addition, the cut off (0.90-1.00) of ABI was independently associated with inter-arm SBP difference ≥ 15mmHg and inter-ankle DBP difference ≥ 10mmHg or ≥ 15mmHg. Hence, detection of limbs blood pressure difference with simultaneous measurement may provide an aid for the non-invasive diagnostic method of peripheral artery disease in clinical primary care.