The objective of this study is to evaluate the residual capacity of the damaged RC slab by the combined blast and fragment loading (CBFL) effects.  High-fidelity physics-based (HFPB) finite element (FE) analysis is used for the numerical simulations in this study, which takes into account material nonlinearity, strain rate effects, large deformation behavior, “real time” blast and fragment loading, and actual supporting boundary conditions.  Numerical model and simulation techniques have been validated through five tests including the quasi-static tests, the blast loading only test and the CBFL tests, in comparison of the deformation and pristine/residual loading capacity of the RC slabs, which was carried out without knowing the test results.  Using a fast running tool, fragments and blast loading are generated on full scale RC slabs.  Some parametric study has been done to investigate dynamic response of the full-scale RC slabs under blast loading only and CBFL effects.