Digital volume correlation (DVC) allowed measurements of the internal strain distribution in bone at both tissue and organ level. However, as this technique relies on the quality of the 3D images, it has been mainly used in conjunction with high-resolution microCT or SR-microCT imaging. An evaluation of how the technique could be potentially established as a diagnostic tool in combination with clinical CT is entirely missing to date. In this study a PedCAT clinical CT was used to establish the strain uncertainties produced on bone structure targets that may be relevant for a reliable use of DVC in the clinical practice. In addition FE modeling was used to predict possible force uncertainties to be associated to displacement errors from DVC.