The paper focuses on the quick modal reanalysis for large topological modified structure based on the multiple dynamic condensation model. Firstly，basing on multiple dynamic condensation model of original structure and topological modified structures, with combining the independent mass orthogonalization and Rayleigh-Ritz analysis, the proposed method was generated. Finally, two numerical examples were used to show that the presented method can provide quite efficient and high quality approximation result for modal reanalysis even when large modifications of the structural topology are made.