Urbanization in developing countries such as Brazil has increased local demands of concrete production and quality control. Understanding and predicting the thermal behavior of mass concrete structures can help engineers reduce the probability and incidence of crack formation, helping to ensure concrete dura- bility. Classical engineering solutions to determine concrete temperature comprise large-scale mockups, which are rather expensive. Alternatively, thermal analyses of concrete are carried out through finite ele- ment method (FEM) models in combination with hydration models. In this work, a multiscale approach that combines semi-adiabatic calorimeter measurements and FEM analysis is applied to simulate the thermal behavior of hydrating concrete; specifically, simulation results are validated on a 511 m3 block.